What’s New??? Reproductive Medicine

Понравилась презентация – покажи это...

Слайд 0

What’s New??? Reproductive Medicine Gana Hospital

Слайд 1

Why!!! To be updated To modify To share

Слайд 2


Слайд 3

Brain Progesterone can be produced in the brain from steroid precursors. they have been found to have neuroprotective function.

Слайд 4

Progesterone for acute brain trauma

Слайд 5

Progesterone & Preterm labor Mainly for prevention of preterm labor But still there are many preterm labor Liable to cerebral palsy and delayed neural development

Слайд 6

Idea Progesterone after preterm labor For the preterm baby

Слайд 7

Why To protect the fetal brain To improve brain development

Слайд 8

Preterm fetus: Deprived from P4

Слайд 9

Trottet et al, 2012 First case preterm baby having progesterone therapy Future

Слайд 10

Genomic Sequencing The coming Era

Слайд 11

DNA sequencing Rapidly evolving Allow genetic diagnosis of diseases Allow prediction for disease later in life Determine human genome in details Now Next generation Sequencer

Слайд 12

Work flow of conventional versus second-generation sequencing

Слайд 13

1. Prepare genomic DNA 2. Attach DNA to surface 3. Bridge amplification 4. Fragement become double stranded 5. Denature the double stranded molecules 6. Complete amplification Illumina ABI SOLiD Roche 454 HeliScope What is next-generation sequencing ?

Слайд 14

7. Determine first base 8. Image first base 9. Determine second base 10. Image second base 11. Sequence reads over multiple cycles 12. Align data. 1 billion bases per run, 1% of the cost of capillary-based method.

Слайд 15

Preimplantation Genetic Diagnosis (PGD)

Слайд 16

Which Embryo is Disease-Free?

Слайд 17

Non Invasive Prenatal Diagnosis Minimise the need for amniocenecis Cell free DNA (fetal in maternal blood) High accuracy

Слайд 18

Towards Better Gene Therapy

Слайд 19

Spindle transfer !!!!! spindle-chromosomal complex transfer taking nuclear DNA from an egg cell and transferring that DNA into another egg cell, leaving the defective mitochondrial DNA behind For genetic disease Safety?????? Gene therapy

Слайд 20

Back to Simple Ideas

Слайд 21

High dose FSH at hCG triggering Novel concept Give four ampoules of FSH at time of hCG injection Why??????

Слайд 22

LH surge is associated with FSH surge to a lesser extent

Слайд 23

Outcome?? 10% increase in PR??

Слайд 24

Corifolitropin alfa Long acting FSH Under the name of Elonva Single shot Contraindicated with PCOS Not self administered Not cheaper

Слайд 25

Increasing LBR with Diagnostic Hysteroscopy

Слайд 26

Dienogest 19-nortestosterone derivative Endometriosis Menorrhagia COC Pituitary suppression

Слайд 27

DNG in endometriosis no glucocorticoid no antimineralocorticoid activity. no antiestrogenic activity due to DNG's low gonadotropic activity, E2 levels are not decreased to zero, in contrast to treatments with gonadotropin-releasing hormone (GnRH) analogues.

Слайд 28

COC This maintenance beneficial E2 effects is of particular importance for the general tolerability of the first contraceptive pill to use E2V instead of EE safer??

Слайд 29

Ulipristal acetate & Fibroids oral selective progesterone receptor modulator (SPRM) that has successfully completed phase III clinical trials. licensed in Western Europe has shown efficacy with a significant reduction in uterine bleeding, fibroid volume, and improved quality of life low side effects unlike (GnRH) agonists.

Слайд 30

Thank you Professional Diploma in Reproductive Medicine